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Karius // curing infectious diseases thru next-gen sequencing
Redwood City, CA    Posted: Wednesday, March 11, 2020
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Karius is a venture-backed life science startup focused on transforming the way infectious diseases are diagnosed.  Combining Next-Generation Sequencing & proprietary data analysis, we can identify over 1,000 pathogens from a single blood sample with typical turnaround time in one business day. By unlocking the information present in microbial cell-free DNA, we're helping doctors quickly solve their most challenging cases, with a future vision of accelerating clinical trials, discovering new microbes, & reducing patient suffering worldwide.
Position Summary
We are looking for an extraordinary scientist to develop NGS-based clinical diagnostic assays into robust clinical products. The ideal candidate will design & execute superior assay development plans, optimize assays for astounding efficiency & robustness, identify in-line quality control measures that ensure industry-leading data integrity.  If you are highly experienced in developing novel diagnostic approaches for nucleic acid detection as well as assay optimization, have worked extensively with NGS workflows & are eager to do the best work of your life, we should talk!
Reports to          Director, Research
Location             Redwood City, CA
      Independently generate & evaluate new methods, technologies & processes.
      Design & execute experiments that ensure efficient & robust protocols
      Achieve an ideal balance of assay integrity & work-flow simplicity through clever in-line quality control measures & assay monitoring strategies
      Enable operational superiority through workflows compatible with automation
      Assist in the design & execution of analytical & clinical validation studies
     Act as a key contributor within integrated & multidisciplinary teams developing new & improving existing clinical assay.
      Create & maintain SOPs in the context of CLIA/CAP environment
      Perform calculations & data analysis
      Generate new IP to maintain Karius' leadership position in the field of infectious disease diagnostics.
      Perform other duties, as needed
Travel:              No travel required
Physical Requirements: 
Subject to extended periods of sitting and/or standing, vision to monitor & moderate noise levels. Work is generally performed in an office, lab or clinical environment.
Position Requirements:
      PhD with minimum 5 years relevant experience building robust diagnostic products
      Demonstrated proficiency taking clinical diagnostic assays through research & development
      Experience with product development in CLIA/CAP or IVD environments
      Follow GLPs & SOPs, & adhere to all safety & company policies
      Expertise with RNA- and/or DNA-based Next-Generation Sequencing sample preparation technologies
Personal Qualifications:
      Must be an excellent communicator & able to summarize key findings, risks in a succinct manner including the ability to present information to stakeholders
      Ability to anticipate & identify potential roadblocks to meeting goals & identify corrective actions
      Display a high level of commitment & professionalism & is truly passionate about being at the cutting edge of science & generating the appropriate clinical evidence
      Ability to work independently, collaboratively & manage deadlines
      Exemplary project management skills with the ability to build schedules & mitigate against timeline delays
       Strong communication & presentation skills
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