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You + Helix

Helix is a place where innovators & doers gather in order to drive significant progress in population genomics. We have come together to work at the intersection of clinical care, research, & genomics.  

If youre excited by the idea of making a meaningful impact & joining a team where we pride ourselves on driving innovation through fostering an environment with an emphasis on empowering one another to grow, Helix might be the place for you!

Helix + The World

Our end-to-end population genomics platform enables health systems, life sciences companies, & payers to advance genomic research & accelerate the integration of genomic data into routine clinical care. We support all aspects of population genomics from recruitment to translational research & help our partners use genomics to improve health outcomes, increase patient engagement, & lower costs.   Leading health systems, including Renown Health, AdventHealth, & Mayo Clinic, use our population genomics platform to power some of the worlds largest & fastest-growing population genomics initiatives.

For the COVID-19 public health crisis, Helix has built one of the nations largest COVID diagnostic labs & has been on the leading edge of national viral surveillance efforts tracking B.1.1.7 & other viral strains.  

What is special about this role:

Helix provides a first-in-class clinico-genomics research dataset for our partners to conduct & publish cutting-edge genomic studies. Working closely with our Research & Research Platform teams, you will enable our partners success in leveraging their EHR data together with our Exome+ sequencing data for discovery of novel genomic risks of disease, patient finding for clinical studies, to aid clinical decision support, & improve care pathways.  The patient is top of mind in everything we do, & your contributions here have the opportunity to improve the real world outcomes for each & every one.

As a Research Applications Scientist, you will:

  • Be a trusted bioinformatics advisor to Helixs Health System Partners delivering training, developing solutions on occasion, & ensuring our partners scientists & technical staff succeed with ongoing research goals 
  • Deepen your expertise in software, bioinformatics, & genomics by collaborating with scientists at the world's top clinical & research centers
  • Provide input into scientific product development through needs identification, designing automations pipelines, & performing feasibility studies
  • Promote confidence in Helix products through successful Proof of Concept projects
  • Identify & define solutions that meet client requirements
  • Develop strong internal relationships while working cross-functionally with our Research, Research Platform, Product, & Partnerships teams
  • Be the scientific face of Helix to our clients


About you:

  • Ph.D. + 2 years postdoc in bioinformatics, computational biology, computer science, or related biotechnology field; or M.S. plus at least 5 years experience in bioinformatics, biostatistics, genomics, statistical genetics, population genetics, systems biology, and/or translational research in either academic or industry settings
  • Experience working with large-scale genomic datasets, e.g. UKBiobank, AllofUs, 1000 Genomes, ExAC/gnomAD
  • Familiarity with statistical genetics methods & tools including GWAS (PLINK, HAIL, BOLT-LMM, SAIGE, RVtests, SKAT, METAL), PheWAS (PLATO, PHESANT), Polygenic Risk Score analysis (PRS), Mendelian randomization, fine mapping, gene burden
  • Knowledge of the benefits & challenges of cloud-based data management & analysis, including hands-on experience with cloud computing
  • Experience with high-performance computing & database management tools such as SQL, Spark, Hive, & Hadoop
  • Demonstrated history of innovation, with the ability to independently identify creative, pragmatic solutions on tight timelines
  • Love to work with diverse scientists & informaticians, dive into & learn new areas quickly
  • Excellent leadership qualities, interpersonal skills, & verbal & written communication skills
  • Desire to learn & grow in healthcare industry
  • Strong programming skills in Python, R, & SQL
  • Adaptable in a fast-paced startup environment where priorities may change quickly & frequently



  • Previous experience in a client-facing science position and/or in a scientific applications role, working directly with partners in healthcare and/or in the life sciences industry.
  • Experience performing data analysis, preferably data mining, pattern recognition, statistical, and/or mathematical programming & modeling to health-related data
  • Experience with cloud-based computational platforms such as DNANexus, Terra, Databricks, etc.
  • Strong publication record

Whats important to us:

  • Curiosity we are all passionate about the possibilities enabled by having access to your own genome
  • Responsibility we have an obligation to people & our partners to operate with highly credible research guided by well respected advisors, with clear & effective communication about our products
  • Agility flexibility & a desire to be nimble, smart, & effective are important to the Helix culture
  • Follow-through were building a diverse team with amazing track records of achievement in multidisciplinary environments

What Helix has to offer you:

Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, & thoughtful people, we also provide great benefits:

  • Competitive compensation, Comprehensive Health insurance package including employer sponsored HSA 
  • 12 weeks of Maternity or Paternity leave
  • 401(k) with employer matching & 100% vested on first day
  • Corporate fitness rate 
  • Comprehensive Well Being benefits
  • Catered meals 
  • Flexible PTO

Helix is proud to be an equal opportunity employer, & committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth & breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, & local laws.

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