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Company Description


Guardant Health develops breakthrough diagnostic technologies to improve cancer management. With Guardant360, we offer real-time, biopsy-free tumor sequencing that tracks tumor genomics in real-time & identifies associated treatment options. The assay is used by more than 6,000 oncologists & we partner with more than 50 biopharma companies.

Guardant Health raised over $550M from Sequoia Capital, Khosla Ventures, Lightspeed Ventures, OrbiMed & Softbank, before having a successful IPO on NASDAQ in 2018. Guardant is led by a seasoned management team of thought leaders & successful serial entrepreneurs in next generation sequencing & rare cell diagnostics. They are advised by an oncologist-led medical steering committee from leading cancer centers.

Job Description

To enable Guardant Health to lead the disruption of cancer treatments through non-invasive cancer screening, the Technology Development Team is seeking a highly motivated Senior Scientist to help test & validate novel technologies for rare variant studies with next-generation sequencing in a regulated environment. At Guardant, we leverage the most advanced technologies & work with leaders in many different fields to create the most impactful & meaningful technologies for cancer management.

As a Senior Scientist in the Technology Development Team, you will work with members within the team & interface with multiple teams including process engineering, clinical operations, research operations, & bioinformatics. You will be hands on in the lab & be required to design, implement, & validate new technologies related to liquid biopsy sequencing assays for the early detection, treatment, & monitoring of all cancer types.

Essential Duties & Responsibilities:

  • Be able to work in a team environment & independently to develop, test & validate technologies for rare variant studies with next-generation sequencing
  • Think creatively & apply knowledge to design & validate control assays for building oncology diagnostics NGS workflows & reagent components
  • Document product development requirements & validation results
  • Be highly committed & deliver results in a fast-paced start-up environment

  • 3-5 years (Scientist II) 5-8 years (Senior Scientist) of experience in genomics or molecular biology, preferably developing IVDs
  • Strong background in molecular biology
  • Experience in development or optimization of nucleic acid technologies with a strong preference related to sequencing-based genomic assays, preferably in regulated environments.
  • Hands on technical knowledge of NGS library preparation, target enrichment, & rigorous product development practices
  • Experience with bioinformatics analysis of NGS data
  • Comfort with data analysis tools (R, Python, JMP, IGV, etc)
  • Excellent interdisciplinary communication skills
  • Good organization skills, & detailed orientated
  • Self-driven & strong team player with proven track record


  • Experience with development under a regulated environment (FDA QSR/ISO13485/ISO15189)
  • 3+ years of experience in biotech industry preferably in cell-free nucleic acids and/or NGS field
  • Experience with liquid handling platforms is a plus
  • Sense of Humor

Additional Information

All your information will be kept confidential according to EEO guidelines.

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