Chaolin Zhang, PhD
Department of Systems Biology
Department of Biochemistry & Molecular Biophysics
Motor Neuron Center
Columbia University Medical Center
"Dynamic Regulation of Transcriptome Diversity During Neural Development"
Dr. Chaolin Zhang will talk about his lab's recent work on systematic dissection of transcriptome diversity generated by dynamic alternative splicing switches during neural development. A focus is on the scale & timing of these switches & the underlying regulatory mechanisms. He will also talk about the lab's work on the Rbfoxs proteins, a family of RNA-binding proteins implicated in autism & other neurologic disorders, & how they regulate neuronal excitability during development.
Dr. Chaolin Zhang is an Assistant Professor in Department of Systems Biology, Department of Biochemistry & Molecular Biophysics, & Motor Neuron Center at Columbia University. His lab uses an integrative approach to study neuronal RNA-binding proteins & how they regulate the transcriptomic diversity in the nervous system through alternative splicing in both normal & disease contexts. A current focus of the lab is to elucidate mechanisms underlying the precise timing of dynamic transcript isoform switches & the functional consequences during neural development. These works are done in model systems including in vitro neural differentiation from embryonic stem cells & mice. Dr. Zhang's work has contributed to mapping protein-RNA interactions at single nucleotide resolution, to constructing neuronal RNA regulatory networks with high sensitivity & specificity, & to dissecting their function in neurodevelopment.
To learn more about Dr. Chaolin Zhang's research, visit - Google Scholar: Chaolin Zhang, PhD